| Date | Opponent | Location | Time (CST) |
| Sat, Aug 20 | Cardinal/Gold Scrimmage (Exh.) | Ames, Iowa | 3:00 p.m. |
| Fri, Aug 26 | Cincinnati | at DeKalb, Ill. | 2:00 p.m. |
| Sat, Aug 27 | IUPUI | at DeKalb, Ill. | 10:00 a.m. |
| Sat, Aug 27 | Northern Illinois | at DeKalb, Ill. | 2:00 p.m. |
| Fri, Sep 02 | Southern Mississippi (Iowa State Challenge) | Ames, Iowa | 12:00 p.m. |
| Fri, Sep 02 | Arizona State (Iowa State Challenge) | Ames, Iowa | 6:30 p.m. |
| Sat, Sep 03 | Iowa (Iowa State Challenge - Iowa Corn Cy-Hawk Series) | Ames, Iowa | 2:00 p.m. |
| Mon, Sep 05 | Florida | at Gainsville, Fla. | 1:00 p.m. |
| Fri, Sep 09 | North Dakota State | at Fargo, N.D. | 7:00 p.m. |
| Sat, Sep 10 | North Dakota State | at Fargo, N.D. | 1:00 p.m. |
| Tue, Sep 13 | Northern Iowa | at Cedar Falls, Iowa | 7:00 p.m. |
| Sat, Sep 17 | Nebraska | at Lincoln, Neb. | 8:00 p.m. |
| Wed, Sep 21 | Missouri * | Ames, Iowa | 7:00 p.m. |
| Sat, Sep 24 | Texas Tech * | at Lubbock, Texas | 6:30 p.m. |
| Wed, Sep 28 | Kansas * | at Lawrence, Kan. | 6:30 p.m. |
| Sun, Oct 02 | Texas * | Ames, Iowa | 12:00 p.m. |
| Wed, Oct 05 | Kansas State * | at Manhattan, Kan. | 7:00 p.m. |
| Sat, Oct 08 | Oklahoma * | Ames, Iowa | 6:30 p.m. |
| Sat, Oct 15 | Baylor * | Ames, Iowa | 6:30 p.m. |
| Sat, Oct 22 | Texas A&M * | at College Station, Texas | 6:30 p.m. |
| Wed, Oct 26 | Kansas * | Ames, Iowa | 6:30 p.m. |
| Fri, Oct 28 | Texas * | at Austin, Texas | 6:30 p.m. |
| Wed, Nov 02 | Oklahoma * | at Norman, Okla. | 7:00 p.m. |
| Sat, Nov 05 | Texas Tech * | Ames, Iowa | TBA |
| Wed, Nov 09 | Missouri * | at Columbia, Mo. | 6:30 p.m. |
| Wed, Nov 16 | Kansas State * | Ames, Iowa | 6:30 p.m. |
| Sat, Nov 19 | Baylor * | at Waco, Texas | TBA |
| Sat, Nov 26 | Texas A&M * | Ames, Iowa | 6:30 p.m. |
| Thu, Dec 01 - Sun, Dec 04 | NCAA First and Second Rounds | at TBA | TBA |
| Thu, Dec 08 - Sun, Dec 11 | NCAA Regional | at TBA | TBA |
| Thu, Dec 15 - Sat, Dec 17 | NCAA Championship | at San Antonio, Texas | TBA |
| * Conference Games | | | |